Lescol XL for Reduction of Cholesterol Essay Example | Topics and Well Written Essays - 1000 words

Lescol XL for Reduction of Cholesterol - Essay ExampleMore frequently, however, this condition is better termed as hyperlipidemia or high serum lipid levels. Hyperlipidemia is a major cause of atherosclerosis and atherosclerosis-associated conditions, such as coronary heart disease (CHD), ischemic cerebrovascular disease, and peripheral vascular disease, where purposeless lipid is deposited in the arterial walls of different parts of the body, and this lipid is peroxidized to form atherosclerotic plaques. The anatomic constricting of the arterial lumen compromises the blood flow in the area distal to the location of the plaque buildup, and if the artery happens to be a major end artery, there is always a chance of critical ischaemia leading to adverse clinical events such as myocardial infarction, such as occurs in heart. However, in general this drug is indicated for hyperlipidemia and heterozygous familial high cholesterol levels in the serum. High levels of cholesterol in the b lood have been long acknowledged as the prime pathophysiological culprit that causes atherosclerotic cardiovascular disease and peripheral vascular disease. ... One of the major functions of the liver in lipid metabolism is lipoprotein synthesis. The cardinal major classes of circulating plasma lipoproteins are chylomicrons, very low density lipoproteins (VLDLs), low-density lipoproteins (LDLs), and high-density lipoproteins (HDLs). Dyslipidemia, including hyperlipidemia or hypercholesterolemia and low levels of high-density-lipoprotein cholesterol (HDL-C), are major causes of increased atherogenic risk. It has been observed that both genetic disorders and life style associated problems, such as, sedentary behavior and diets high in calories, saturated fat, and cholesterol, contribute to the dyslipidemias. The disease process is cognise as atherosclerosis. Atherosclerosis is a process of progressive lipid accumulation and calcification of the inner arterial walls in the abdominal aorta, lower extremities and the arteries of the heart, brain and kidneys. These lipid depositions contain and the most important single factor for their nurture is a high plasma assiduousness of total cholesterol, in particular a high concentration of LDL (Canto, J.G., and Iskandrian, A.E., 2003). It is very typical for these patients to have a high total cholesterol concentration in the blood plasma, a dangerously high LDL, and a low HDL fraction in self-control plasma. The atherosclerotic patient often also has a high total triglyceride concentration. Large atherosclerotic plaques infinitesimal the arterial lumen and produce arterial stenosis with reduced blood flow. Insufficient oxygen rake to the tissue is called ischaemic hypoxia, and hypoxic pains develop as in angina pectoris and intermittent claudication. Total cylinder block of the arterial lumen is caused by a thrombus